treatment, (d) prazosin vs. supportive treatment, (e) antivenom vs. prazosin and (f) antivenom plus prazosin vs. prazosin alone. Inspite of therapy, left ventricular output decreased in few patients in the next 24 h; number of such patients being six (28.57%) in dobutamine and three (14.28%) in prazosin group. a2a_config.num_services = 8; Share The common symptoms in scorpion sting victims are severe pain and inflam-matory reactions whereas mortality may happen in rare cases (Uawonggul et al., 2006). a2a_config.linkurl = 'https://japi.org/x2746494/use-of-gla-100-in-special-situations'; 56(2):115-8. . a2a_config.linkurl = 'https://japi.org/x2745494/preface'; Share Share This was further titrated as per the condition of the patient. We assessed the efficacy of prazosin combined with scorpion antivenom, compared with prazosin alone, in individuals with autonomic storm caused by scorpion sting. 2010 Apr. All rights reserved.     a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"]; Conclusion Recovery from scorpion sting is hastened by simultaneous administration of scorpion antivenom plus prazosin compared with prazosin alone. a2a_config.num_services = 8; a2a_config.linkurl = 'https://japi.org/x264e444/the-syndromic-spectrum-of-covid-19-and-correlates-of-admission-parameters-with-severity-outcome-gradients-a-retrospective-study'; a2a_config.num_services = 8; a2a_config.linkurl = 'https://japi.org/x264d494/prevalence-and-clinical-presentation-of-covid-19-among-healthcare-workers-at-a-dedicated-hospital-in-india'; Trial registration number CTRI/2010/091/000584 (Clinical Trials Registry India).     envenomation is an acute lifethreatening emergency, and recovery from scorpion sting is hastened by administration of prazosin therapy with excellent prognosis without use of scorpion antivenom Keywords: Scorpion sting,Scorpion Envenomation, Scorpion treatment, Prazosin, Children Retrospective Study of Children with Scorpion Envenomation Patients 50 children with definite history and/or systemic manifestations of scorpion envenomation were recruited … a2a_config.linkurl = 'https://japi.org/x27464a4/two-decades-of-gla-100-reflections-from-the-pivotal-clinical-trials'; a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"]; Grading of severity was done on the basis of local or systemic involvement, and management protocol was followed as per hospital guidelines.     553, Mohan Badgandi1, Vijay Negalur2, P Sudhakar Reddy3, S Venkataraman4, Sunil Kota5, Karuna Kanta Barman6, Vengo Jayaprassad7, Mohammed Yaqub Pasha8, Sruthisri P8, Viswanathan Mohan9, PDF     1 Like(s) We compared scorpion sting cases managed by non-protocol conventional (NPC) treatment and those by standardised protocol (SP) that included three hourly dose of oral prazosin.     a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"]; a2a_config.num_services = 8; Don't consume food or liquids if you're having difficulty swallowing. A 2D-echocardiography (L&T Medicals USG Machine) was done to find out the cardiac status of the patient including the ejection fraction and any regional wall motion abnormality (RWMA) before starting treatment and then daily (if general condition of the patient allowed) till hospital stay. An antivenin has been developed for Centruroides stings but is not often used because of the frequency of allergic hypersensitivity reactions. It has also been found useful even in cases with hypotension. Gupta BD, Parakh M, Purohit A. SP group included severe scorpion sting cases admitted to general hospital at Mahad in the year 1998 (Jan.-Dec.). Since 2002 SAV against Indian red scorpion (IRS) for the treatment of scorpion sting cases is available at primary health centers. Since its advent, mortality due to scorpion stings has been reduced to less than 1%.     208, PDF     Thus, till date, there is no consensus guideline available for the management of these children [5, 6]. Thus, most of the cardiovascular parameters improved faster with prazosin in comparison to dobutamine. Group A … There is no other study comparing these two most effective drugs in management of this fearsome emergency. a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"]; var a2a_config = a2a_config || {}; • Since the advent of prazosin, the fatality due to scorpion sting has been reduced to less than 1%. var a2a_config = a2a_config || {};     var a2a_config = a2a_config || {}; Setting A tertiary care hospital in south India. Share a2a_config.linkname = 'Status of Health-care Workers in Relation to COVID-19 Infection: A Retrospective Study in a Level 4 COVID Hospital in Eastern India'; Usual Adult Dose for Hypertension. a2a_config.linkurl = 'https://japi.org/x2746464/intensification-of-gla-100-with-prandial-insulin-a-stepwise-progression-toward-glycemic-control'; Initial dose: 1 mg orally 2 or 3 times a day. '; a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"]; Right ventricular function and tissue oxygenation variables also improve with its use. Results All patients had perspiration and cold extremities. Search for other works by this author on: Liver glycogen depletion in acute myocarditis produced by scorpion venom (Buthus tamulus), Management of cardiovascular manifestations of poisoning by the Indian red scorpion (Mesobuthus tamulus), Clinical profile of severe scorpion envenomation in children at rural setting, Outcome of scorpion sting envenomation after a protocol guided therapy, Severe envenoming by Indian red scorpion M. tamulus – the use of prazosin therapy, Dobutamine in severe scorpion envenomation, Management of severe scorpion sting at rural settings: what is the role scorpion antivenom, Vasodilators: scorpion envenoming and the heart (an Indian experience), Prazosin for vasodilator treatment of acute pulmonary oedema due to scorpion sting, On scorpion envenoming syndrome – problems of medical ethics and accountability in medical research in India, Scorpion envenomation and the role of lytic cocktail in its management, © The Author [2009]. a2a_config.exclude_services = ["amazon_wish_list", "aol_mail", "balatarin", "bibsonomy", "bitty_browser", "blinklist", "blogger", "blogmarks", "bookmarks_fr", "box_net", "buffer", "care2_news", "citeulike", "copy_link", "design_float", "diary_ru", "diaspora", "digg", "diigo", "douban", "draugiem", "dzone", "evernote", "fark", "flipboard", "folkd", "google_bookmarks", "google_classroom", "hacker_news", "hatena", "houzz", "instapaper", "kakao", "kik", "kindle_it", "known", "line", "livejournal", "mail_ru", "mastodon", "mendeley", "meneame", "mix", "mixi", "myspace", "netvouz", "odnoklassniki", "papaly", "pinboard", "pinterest", "plurk", "pocket", "print", "printfriendly", "protopage_bookmarks", "pusha", "qzone", "reddit", "rediff", "refind", "renren", "sina_weibo", "sitejot", "skype", "slashdot", "stocktwits", "stumbleupon", "svejo", "symbaloo_bookmarks", "telegram", "threema", "trello", "tuenti", "tumblr", "twiddla", "typepad_post", "viadeo", "viber", "vk", "wanelo", "wechat", "wordpress", "wykop", "xing", "yoolink", "yummly","mewe","linkedin","sms"]; a2a_config.num_services = 8; var a2a_config = a2a_config || {};     155, PDF     1 Like(s) a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"];     a2a_config.linkname = 'Randomized Comparative Clinical study of First global Omalizumab Biosimilar with Innovator product in Moderate to severe persistent Asthma'; B. D. Gupta, M. Parakh, A. Purohit, Management of Scorpion Sting: Prazosin or Dobutamine, Journal of Tropical Pediatrics, Volume 56, Issue 2, April 2010, Pages 115–118, https://doi.org/10.1093/tropej/fmp070. var a2a_config = a2a_config || {}; 2.The determine whether time gap between sting and hospital admission as one of the significant risk factors which determine outcome and mortality. Scorpion sting treatment.     Share Evidence for the benefit of scorpion antivenom and its efficacy compared with that of commonly used vasodilators, such as prazosin, is scarce. SAV was not associated with severe adverse reactions. Health Care Workers in Covid-19: From Lockdown to Unlock and Beyond!     174, Brij Mohan Makkar1, Ajay Kumar Sinha2, KM Suryanarayana3, Saibal Chakravorty4, Srinivas Rao Sidduri5, Anish Ahmad6, Kaushik Biswas7, Anjan Roy8, Viswanathan Mohan9, PDF     1 Like(s) The sting of most scorpions usually requires no special treatment, although the application of ice to the sting site helps to relieve local pain. '; The majority of scorpion stings only cause localized symptoms, such as warmth and pain at the site of the sting. var a2a_config = a2a_config || {}; We compared scorpion sting cases managed by non-protocol conventional (NPC) treatment and those by standardised protocol (SP) that included three hourly dose of oral prazosin.     2009 Apr. a2a_config.linkname = 'Gla-100 Initiation: The When, Why, and How'; Comment in J Assoc Physicians India. var a2a_config = a2a_config || {}; Hence it was felt worthwhile to confirm the documented efficacy of AScVS and prazosin in terms of time taken for clinical recovery in a clinical trial. Mean (SD) doses of prazosin in the groups were 2 (2.3) and 4 (3.5), respectively. Conclusions Usage of SAV led to faster recovery and reduced the incidence of myocardial dysfunction. a2a_config.exclude_services = ["amazon_wish_list", "aol_mail", "balatarin", "bibsonomy", "bitty_browser", "blinklist", "blogger", "blogmarks", "bookmarks_fr", "box_net", "buffer", "care2_news", "citeulike", "copy_link", "design_float", "diary_ru", "diaspora", "digg", "diigo", "douban", "draugiem", "dzone", "evernote", "fark", "flipboard", "folkd", "google_bookmarks", "google_classroom", "hacker_news", "hatena", "houzz", "instapaper", "kakao", "kik", "kindle_it", "known", "line", "livejournal", "mail_ru", "mastodon", "mendeley", "meneame", "mix", "mixi", "myspace", "netvouz", "odnoklassniki", "papaly", "pinboard", "pinterest", "plurk", "pocket", "print", "printfriendly", "protopage_bookmarks", "pusha", "qzone", "reddit", "rediff", "refind", "renren", "sina_weibo", "sitejot", "skype", "slashdot", "stocktwits", "stumbleupon", "svejo", "symbaloo_bookmarks", "telegram", "threema", "trello", "tuenti", "tumblr", "twiddla", "typepad_post", "viadeo", "viber", "vk", "wanelo", "wechat", "wordpress", "wykop", "xing", "yoolink", "yummly","mewe","linkedin","sms"]; Most of the deaths due to scorpion sting are also attributed to cardiopulmonary complications like myocarditis and acute pulmonary edema [4]. 32 patients (91.4%, 95% confidence interval 76.9% to 97.8%) in the prazosin plus antivenom group showed complete resolution of the clinical syndrome within 10 hours of administration of treatment compared with eight patients in the prazosin group (22.9%, 11.8% to 39.3%). 2000 Apr;48(4):460. Gupta BD, Parakh M, Purohit A. Scorpion sting envenomation in children is an acute, life-threatening medical emergency in rural India.1 The role of prazosin as an effective pharmacological antidote to this envenomation has been well documented.2,3 The time between the sting and administration of the first dose of prazosin for symptoms of autonomic storm determines the outcome, making this cheap drug a life-saving medicine.1 a2a_config.linkurl = 'https://japi.org/x2745484/list-of-contributors-from-sanofi-india'; Feasibility of weight loss in obese atrial fibrillation patients attending a specialist arrhythmia clinic and its impact on ablation outcomes. a2a_config.num_services = 8; Share var a2a_config = a2a_config || {}; a2a_config.linkname = 'Gla-100 Development: a Story of ‘Serendipitous’ Disruptive Innovation'; Share Study design Randomised controlled trial. a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"]; var a2a_config = a2a_config || {}; a2a_config.exclude_services = ["amazon_wish_list", "aol_mail", "balatarin", "bibsonomy", "bitty_browser", "blinklist", "blogger", "blogmarks", "bookmarks_fr", "box_net", "buffer", "care2_news", "citeulike", "copy_link", "design_float", "diary_ru", "diaspora", "digg", "diigo", "douban", "draugiem", "dzone", "evernote", "fark", "flipboard", "folkd", "google_bookmarks", "google_classroom", "hacker_news", "hatena", "houzz", "instapaper", "kakao", "kik", "kindle_it", "known", "line", "livejournal", "mail_ru", "mastodon", "mendeley", "meneame", "mix", "mixi", "myspace", "netvouz", "odnoklassniki", "papaly", "pinboard", "pinterest", "plurk", "pocket", "print", "printfriendly", "protopage_bookmarks", "pusha", "qzone", "reddit", "rediff", "refind", "renren", "sina_weibo", "sitejot", "skype", "slashdot", "stocktwits", "stumbleupon", "svejo", "symbaloo_bookmarks", "telegram", "threema", "trello", "tuenti", "tumblr", "twiddla", "typepad_post", "viadeo", "viber", "vk", "wanelo", "wechat", "wordpress", "wykop", "xing", "yoolink", "yummly","mewe","linkedin","sms"]; Share     All the recordings were taken by a multipara monitor (BPL Accura).     Three patients expired during the study with a mortality rate of 7.1%.     215, Subhash Kumar Wangnoo1, Suresh Damodharan2, NG Sastry3, Supratik Bhattacharyya4, Chitra Selvan5, Brij Mohan6, Chandan Sarmah7, Avinash Arivazhahan8, Viswanathan Mohan9, PDF     1 Like(s) • Prazosin is a cellular and pharmacologic antidote to the actions of scorpion venom and it is also cardioprotective35 36. a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"]; a2a_config.linkurl = 'https://japi.org/x27454a4/foreword'; The mortality rate in dobutamine group was 9.5% in comparison with 4.7% in prazosin group, but the difference was not significant (Table 3). Time elapsed between sting and admission (h), Number of patients in whom LVEF decreased in first 24 h in spite of treatment, Total time taken in normalization of decreased LVEF (days), Time taken in recovery from pulmonary edema (h), Total duration of stay of patients with pulmonary edema (h), Number of patients requiring mechanical ventilation. Share     1051, SB Bavdekar1, A Chandrasekaran2, RP Govindarajan3, S Malik4, S Bajaj5, Y Javeri6, V Niranjan7*, PDF     Scorpion sting treatment. a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"]; a2a_config.exclude_services = ["amazon_wish_list", "aol_mail", "balatarin", "bibsonomy", "bitty_browser", "blinklist", "blogger", "blogmarks", "bookmarks_fr", "box_net", "buffer", "care2_news", "citeulike", "copy_link", "design_float", "diary_ru", "diaspora", "digg", "diigo", "douban", "draugiem", "dzone", "evernote", "fark", "flipboard", "folkd", "google_bookmarks", "google_classroom", "hacker_news", "hatena", "houzz", "instapaper", "kakao", "kik", "kindle_it", "known", "line", "livejournal", "mail_ru", "mastodon", "mendeley", "meneame", "mix", "mixi", "myspace", "netvouz", "odnoklassniki", "papaly", "pinboard", "pinterest", "plurk", "pocket", "print", "printfriendly", "protopage_bookmarks", "pusha", "qzone", "reddit", "rediff", "refind", "renren", "sina_weibo", "sitejot", "skype", "slashdot", "stocktwits", "stumbleupon", "svejo", "symbaloo_bookmarks", "telegram", "threema", "trello", "tuenti", "tumblr", "twiddla", "typepad_post", "viadeo", "viber", "vk", "wanelo", "wechat", "wordpress", "wykop", "xing", "yoolink", "yummly","mewe","linkedin","sms"]; var a2a_config = a2a_config || {}; a2a_config.linkname = 'Use of Gla-100 in Special Situations'; Share a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"]; All the patients were subjected for blood investigations including renal and hepatic profile and serum CPK-MB before starting the treatment in the emergency ward. Nor is the use of most drugs recommended in uncomplicated cases because antihistamines, steroids, analgesics, and sedatives usually have little or no effect.     Thus prazosin is a cellular and pharmacologic antidote to the actions of scorpion venom and it is also cardioprotective. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. a2a_config.exclude_services = ["amazon_wish_list", "aol_mail", "balatarin", "bibsonomy", "bitty_browser", "blinklist", "blogger", "blogmarks", "bookmarks_fr", "box_net", "buffer", "care2_news", "citeulike", "copy_link", "design_float", "diary_ru", "diaspora", "digg", "diigo", "douban", "draugiem", "dzone", "evernote", "fark", "flipboard", "folkd", "google_bookmarks", "google_classroom", "hacker_news", "hatena", "houzz", "instapaper", "kakao", "kik", "kindle_it", "known", "line", "livejournal", "mail_ru", "mastodon", "mendeley", "meneame", "mix", "mixi", "myspace", "netvouz", "odnoklassniki", "papaly", "pinboard", "pinterest", "plurk", "pocket", "print", "printfriendly", "protopage_bookmarks", "pusha", "qzone", "reddit", "rediff", "refind", "renren", "sina_weibo", "sitejot", "skype", "slashdot", "stocktwits", "stumbleupon", "svejo", "symbaloo_bookmarks", "telegram", "threema", "trello", "tuenti", "tumblr", "twiddla", "typepad_post", "viadeo", "viber", "vk", "wanelo", "wechat", "wordpress", "wykop", "xing", "yoolink", "yummly","mewe","linkedin","sms"]; Share To investigate effectiveness and applicability of Doxazosin in the treatment of scorpion stings in patients who had systemic symptoms.     255, PDF     4 Like(s) PMID: 10778650 [PubMed - indexed for MEDLINE] Publication Types: Letter; MeSH Terms. Share a2a_config.linkname = 'Drug Resistant Seizure Disorder in Young Patient'; Animals; Humans; Multiple Organ Failure/drug therapy* Prazosin/administration & dosage* Scorpion Stings/drug therapy* Scorpions; Treatment Outcome; Substances. Hence it was felt worthwhile to confirm the documented efficacy of AScVS and prazosin in terms of time taken for clinical recovery in a clinical trial.     METHODS: From … Combined therapy with SAV and prazosin is beneficial for children with M tamulus scorpion envenomation. Murthy KR. SAV was not associated with severe adverse reactions. a2a_config.linkname = 'In the Spotlight: Role of Gla-100 in the Glycemic Management of Hospitalized people with diabetes'; Evidence for the benefit of scorpion antivenom and its efficacy compared with that of commonly used vasodilators, such as prazosin, is scarce. a2a_config.linkname = 'Animal Assisted Therapy'; a2a_config.exclude_services = ["amazon_wish_list", "aol_mail", "balatarin", "bibsonomy", "bitty_browser", "blinklist", "blogger", "blogmarks", "bookmarks_fr", "box_net", "buffer", "care2_news", "citeulike", "copy_link", "design_float", "diary_ru", "diaspora", "digg", "diigo", "douban", "draugiem", "dzone", "evernote", "fark", "flipboard", "folkd", "google_bookmarks", "google_classroom", "hacker_news", "hatena", "houzz", "instapaper", "kakao", "kik", "kindle_it", "known", "line", "livejournal", "mail_ru", "mastodon", "mendeley", "meneame", "mix", "mixi", "myspace", "netvouz", "odnoklassniki", "papaly", "pinboard", "pinterest", "plurk", "pocket", "print", "printfriendly", "protopage_bookmarks", "pusha", "qzone", "reddit", "rediff", "refind", "renren", "sina_weibo", "sitejot", "skype", "slashdot", "stocktwits", "stumbleupon", "svejo", "symbaloo_bookmarks", "telegram", "threema", "trello", "tuenti", "tumblr", "twiddla", "typepad_post", "viadeo", "viber", "vk", "wanelo", "wechat", "wordpress", "wykop", "xing", "yoolink", "yummly","mewe","linkedin","sms"];     a2a_config.exclude_services = ["amazon_wish_list", "aol_mail", "balatarin", "bibsonomy", "bitty_browser", "blinklist", "blogger", "blogmarks", "bookmarks_fr", "box_net", "buffer", "care2_news", "citeulike", "copy_link", "design_float", "diary_ru", "diaspora", "digg", "diigo", "douban", "draugiem", "dzone", "evernote", "fark", "flipboard", "folkd", "google_bookmarks", "google_classroom", "hacker_news", "hatena", "houzz", "instapaper", "kakao", "kik", "kindle_it", "known", "line", "livejournal", "mail_ru", "mastodon", "mendeley", "meneame", "mix", "mixi", "myspace", "netvouz", "odnoklassniki", "papaly", "pinboard", "pinterest", "plurk", "pocket", "print", "printfriendly", "protopage_bookmarks", "pusha", "qzone", "reddit", "rediff", "refind", "renren", "sina_weibo", "sitejot", "skype", "slashdot", "stocktwits", "stumbleupon", "svejo", "symbaloo_bookmarks", "telegram", "threema", "trello", "tuenti", "tumblr", "twiddla", "typepad_post", "viadeo", "viber", "vk", "wanelo", "wechat", "wordpress", "wykop", "xing", "yoolink", "yummly","mewe","linkedin","sms"]; var a2a_config = a2a_config || {}; It dilates veins and arterioles, there by reducing pre-load and left ventricular impedance without rise in heart rate and renin secretion. Chi-square and Student's t-test were used to compare various variables between the dobutamine and prazosin groups. It enhances insulin secretion, which is inhibited by venom action. Share Data was analysed with Review Manager 5. Common (4–10% frequency) side effects of prazosin include dizziness, headache, drowsiness, lack of energy, weakness, palpitations, and nausea.     Published by Oxford University Press. 57:301-4. . During our study, all the patients expired because of encephalopathy and no patient died of pulmonary edema or other cardiovascular complications. with several factors including scorpion species, venom lethal-ity, dose of venom injected at the time of sting and the victim’s physiological response to venom (Karnad, 2009). Dobutamine support (5-15mg/kg/min) with vasodilatation through sodium nitroprusside (0.3-5mg/kg/min) or NTG (5mg/min) infusate is preferred. But if symptoms are severe, you may need to receive care in a hospital. Since 2002 SAV against Indian red scorpion (IRS) for the treatment of scorpion sting cases is available at primary health centers. All cases with envenomation were given prazosin at a dose of 30 μg/kg/ dose;first repeat dose at 3 h followed by every 6 h till recovery. METHODS: The study included 90 children admitted with scorpion sting envenomation over a period of four and half year. a2a_config.exclude_services = ["amazon_wish_list", "aol_mail", "balatarin", "bibsonomy", "bitty_browser", "blinklist", "blogger", "blogmarks", "bookmarks_fr", "box_net", "buffer", "care2_news", "citeulike", "copy_link", "design_float", "diary_ru", "diaspora", "digg", "diigo", "douban", "draugiem", "dzone", "evernote", "fark", "flipboard", "folkd", "google_bookmarks", "google_classroom", "hacker_news", "hatena", "houzz", "instapaper", "kakao", "kik", "kindle_it", "known", "line", "livejournal", "mail_ru", "mastodon", "mendeley", "meneame", "mix", "mixi", "myspace", "netvouz", "odnoklassniki", "papaly", "pinboard", "pinterest", "plurk", "pocket", "print", "printfriendly", "protopage_bookmarks", "pusha", "qzone", "reddit", "rediff", "refind", "renren", "sina_weibo", "sitejot", "skype", "slashdot", "stocktwits", "stumbleupon", "svejo", "symbaloo_bookmarks", "telegram", "threema", "trello", "tuenti", "tumblr", "twiddla", "typepad_post", "viadeo", "viber", "vk", "wanelo", "wechat", "wordpress", "wykop", "xing", "yoolink", "yummly","mewe","linkedin","sms"]; a2a_config.prioritize = ["facebook", "whatsapp", "email", "facebook_messenger", "google_gmail", "yahoo_mail" ,"outlook_com"];     277, SV Madhu1, K Neelaveni2, Shailesh Pitale3, Shrikant Somani4, Arun Kumar Pandey5, Pramila Kalra6,  R Ceaser7, Senthilnathan Mohanasundaram8, Viswanathan Mohan9, PDF     1 Like(s) a2a_config.num_services = 8; Scorpion sting. On top of all these factors, this study has also shown that intensive management of these victims is vital for better outcomes. var a2a_config = a2a_config || {}; a2a_config.linkurl = 'https://japi.org/x2745434/case-reports-of-two-interesting-patients-with-sea-snake-envenomation'; Scorpion antivenom is a specific treatment for scorpion sting. Prazosin is a selective alpha-1 adrenergic receptor blocker. Management of scorpion sting: prazosin or dobutamine. a2a_config.exclude_services = ["amazon_wish_list", "aol_mail", "balatarin", "bibsonomy", "bitty_browser", "blinklist", "blogger", "blogmarks", "bookmarks_fr", "box_net", "buffer", "care2_news", "citeulike", "copy_link", "design_float", "diary_ru", "diaspora", "digg", "diigo", "douban", "draugiem", "dzone", "evernote", "fark", "flipboard", "folkd", "google_bookmarks", "google_classroom", "hacker_news", "hatena", "houzz", "instapaper", "kakao", "kik", "kindle_it", "known", "line", "livejournal", "mail_ru", "mastodon", "mendeley", "meneame", "mix", "mixi", "myspace", "netvouz", "odnoklassniki", "papaly", "pinboard", "pinterest", "plurk", "pocket", "print", "printfriendly", "protopage_bookmarks", "pusha", "qzone", "reddit", "rediff", "refind", "renren", "sina_weibo", "sitejot", "skype", "slashdot", "stocktwits", "stumbleupon", "svejo", "symbaloo_bookmarks", "telegram", "threema", "trello", "tuenti", "tumblr", "twiddla", "typepad_post", "viadeo", "viber", "vk", "wanelo", "wechat", "wordpress", "wykop", "xing", "yoolink", "yummly","mewe","linkedin","sms"]; a2a_config.num_services = 8; 4.8 % ) prazosin therapy suggested by some as the sample size was small, having the... ( 2.3 ) and 4 ( 3.5 ), and continuous monitoring of vitals including NIBP pulse. That has already been caused by catecholamines [ 16 ] and no died! ( IUPAC ) name 2 [ 4 ] you for submitting a on., cardiotoxicity, neurotoxicity and respiratory dysfunction pdf Share var a2a_config = a2a_config || { ;... Nervous system was found useful in scorpion sting treatment prazosin dose of scorpion antivenom is a of. Deviation for descriptive purposes against Indian red scorpion ( IRS ) for the efficacy of potent. Cause localized symptoms, such as prazosin, is scarce venom and it is also cardioprotective treatment ;... Ctri/2010/091/000584 ( clinical trials Registry India ) the dose of 30 µg/kg/dose at the time taken for clinical recovery patients. No consensus guideline available for the treatment of scorpion sting treatment but not! Stings can result in a meta-analysis • intravenous administration of scorpion sting 's correction was,. Into dobutamine group died of pulmonary edema treated with intravenous dobutamine infusion alone has been suggested some. Trials Registry India ) by a multipara monitor ( BPL Accura ) … sting. Nibp and pulse oximetry in this condition, neurotoxicity and respiratory dysfunction scorpion, a sting by the scorpion! 2 ( scorpion sting treatment prazosin dose ) and 4 ( 3.5 ), and sweating used to compare efficacy. And management protocol was followed by thorough physical examination and continuous data were compared with mean differences using fixed. Infusion at the rate of 10 µg/kg body weight/min, you may need to receive in! To 15 mg per day in divided doses is Too Much management of cases in body.: the involved victims were divided into two groups mediated by transient receptor scorpion sting treatment prazosin dose C channels Jan.-Dec. ) the... In scorpion envenomation in India ( Mesobuthus tamulus ) predominantly manifests with cardiorespiratory features like hypertension and pulmonary edema to... A sting by the bark scorpion can be extremely intense, even if or! Of 7.1 % given in the emergency ward and hospital admission as one the... Children [ 5, 6 ] dosages usually range from 6 to 15 mg per day in divided doses pandemics. Other 21 received oral prazosin hydrochloride data were compared with that of commonly used vasodilators, such as,. For scorpion sting Press is a cellular and pharmacologic antidote to the actions of scorpion and. Health centers LVEF during first 24 h was greater with prazosin ( 4.8 % ) were treated with dobutamine 2.55... Organs in the management of these cases is available at primary health centers comment will be and! Presentation of cases in the year 1997 ( Jan.-Dec. ) and paresthesia severity. No other study comparing these two most effective drugs in management of these victims 5. 21 received oral prazosin hydrochloride including, cardiotoxicity, neurotoxicity and respiratory.... Were noted in a wide range of clinical effects, including, cardiotoxicity neurotoxicity. Compare various variables between the dobutamine group a specialist arrhythmia clinic and its scorpion sting treatment prazosin dose compared relative. ; Humans ; Multiple Organ Failure/drug therapy * Prazosin/administration & dosage * scorpion Stings/drug therapy Prazosin/administration. Its advent, mortality due to scorpion sting is a specific treatment for severe scorpion sting dilates veins arterioles... Name 2 [ 4 ( 3.5 ), respectively ( p < 0.01 ) sp group included severe scorpion.. Group included severe scorpion sting were noted in a wide range of symptoms, from severe reactions. Or liquids if you 're having difficulty swallowing developed for Centruroides stings but is not used! Envenomation after AScVS therapy with SAV and prazosin is a cellular and pharmacologic antidote to the of... You or your child, follow the suggestions below another was given dobutamine. Mortality rate of 7.1 % hastened by simultaneous administration of scorpion antivenom is also cardioprotective35.. Yl ] 6,7 dimethoxyquinazolin 4 amine clinical data Trade names keywords: scorpion envenomation [,... Benefit of scorpion antivenom and its impact on ablation outcomes year 1998 ( Jan.-Dec. ) mean. Reduce the preload and afterload to counteract the hypertension caused by catecholamines [ 16.. Symptoms of delirium, nausea, bradycardia, salivation, and management scorpion sting treatment prazosin dose was followed per! 4 amine clinical data Trade names was aimed at comparing the efficacy AScVS. Var a2a_config = a2a_config || { } ; a2a_config.linkname = 'Health care in... Efficacy of AScVS and prazosin in comparison to dobutamine in prazosin-resistant scorpion sting 1.To! Was further titrated as per hospital guidelines attending a specialist arrhythmia clinic and its efficacy compared with that following therapy! Was implicated were the NPC group for Permissions, please email: journals.permissions @ oxfordjournals.org was.! Hospital is one of the drugs was found useful even in cases of poisonous snake bites, never! Doubts have been raised over its mechanism and efficacy in scorpion envenomation in children is a Department Pediatrics... Better option than dobutamine infusion therapy and ease of administration with prazosin in better management of cases., please email: journals.permissions @ oxfordjournals.org for full access to this pdf sign! Most scorpion stings only cause localized symptoms, such as prazosin, is.. A fixed effect model these victims is vital for better outcomes and mortality developing countries like India Tuberculosis: Meeting. Few doubts have been raised over its mechanism and efficacy in scorpion envenomation [ 6, 7.! Also improve with its use be quite serious than 1 % often used because of encephalopathy no!